RNA-seq of human HT-29 WT and SMYD2-KO xenograft implanted into the flanks of Rag1−/− mice. RNA-seq of human HT-29 WT and SMYD2-KO xenograft implanted into the flanks of Rag1−/− mice

Our data suggested that SMYD2 deficiency sensitized cells to apoptosis and necroptosis.To further narrow down the mechanism of cell death induction upon SMYD2 deficiency, RNA-seq analysis was performed on implanted tumor tissues from two clones of SMYD2 deficient and WT HT-29 cells.