PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative
收藏Protein Data Bank Japan2026-02-18 更新2026-03-21 收录
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PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative Descriptor: N-(cyclopropylmethyl)-4-(furan-2-carbonyl)piperazine-1-carboxamide, PH-interacting protein Authors: Grosjean, H, Aimon, A, Hassel-Hart , S, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Biggin, P.C, Spencer, J, von Delft, F. Deposit date: 2021-01-22 Release date: 2021-02-17 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography. Angew.Chem.Int.Ed.Engl., 64, 2025
PanDDA分析组提交数据集——PHIP（PH-interacting protein，即PH互作蛋白）与Z198194396合成衍生物结合的晶体结构。描述符：N-(环丙基甲基)-4-(呋喃-2-羰基)哌嗪-1-甲酰胺、PH互作蛋白。作者：Grosjean, H、Aimon, A、Hassel-Hart, S、Krojer, T、Talon, R、Douangamath, A、Koekemoer, L、Biggin, P.C、Spencer, J、von Delft, F。提交日期：2021-01-22，发布日期：2021-02-17，最后修改日期：2026-02-18。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.24 Å。引用文献：《结合位点活性物质纯化法（Binding-Site Purification of Actives，简称B-SPA）可通过结合多步阵列合成与高通量晶体学（HT Crystallography）实现片段hit化合物的高效规模化开发》，Angew.Chem.Int.Ed.Engl., 64, 2025
创建时间：
2021-01-22
