Endocytosis of protein 3a

This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.<br><br>Protein 3a is rapidly internalized into cells by endocytosis. It contains a Yxxφ motif and also diacidic motifs which are typically found in internalized membrane proteins (Tan et al, 2004). The ability to be internalized is necessary for the protein's pro-apoptotic function (Wong et al, 2006; Chan et al, 2009)

本COVID-19事件系基于SARS-CoV-1数据通过计算推理（参见https://reactome.org/documentation/inferred-events）与人工编辑相结合所构建，具体细节可见于SARS-CoV-2感染途径的整体概述中。<br><br>蛋白质3a可迅速通过内吞作用进入细胞。该蛋白含有Yxxφ基序，并具备典型的二羧酸基序，此类基序通常存在于被内吞的膜蛋白中（Tan等，2004年）。蛋白质的内吞能力对于其促凋亡功能至关重要（Wong等，2006年；Chan等，2009年）。