CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING

CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING Descriptor: 2-HYDROXY-4-AMINOBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE Authors: Schreuder, H.A, Van Der Bolt, F.J.T, Van Berkel, W.J.H. Deposit date: 1994-07-06 Release date: 1994-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring Biochemistry, 33, 1994

野生型对羟基苯甲酸羟化酶(p-hydroxybenzoate hydroxylase)分别与4-氨基苯甲酸、2,4-二羟基苯甲酸、2-羟基-4-氨基苯甲酸结合的晶体结构，以及Tyr222Ala突变体与2-羟基-4-氨基苯甲酸结合的晶体结构：质子通道与黄素环新结合模式的证据
描述关键词：2-羟基-4-氨基苯甲酸、黄素腺嘌呤二核苷酸(flavin-adenine dinucleotide)、对羟基苯甲酸羟化酶
作者：Schreuder, H.A.、Van Der Bolt, F.J.T.、Van Berkel, W.J.H.
提交日期：1994-07-06
发布日期：1994-09-30
最后修改日期：2024-02-14
研究方法：X射线衍射(X-RAY DIFFRACTION，分辨率2.7埃(Å))
引用文献：Schreuder H A, Van Der Bolt F J T, Van Berkel W J H. 野生型对羟基苯甲酸羟化酶分别与4-氨基苯甲酸、2,4-二羟基苯甲酸、2-羟基-4-氨基苯甲酸结合，以及Tyr222Ala突变体与2-羟基-4-氨基苯甲酸结合的晶体结构：质子通道与黄素环新结合模式的证据[J]. 生物化学(Biochemistry), 1994, 33