Growth prediction accuracy in knockout models with constrained reaction directionality.

Reaction deleted only if no functional enzyme complex associated with the reaction remains after knockout. Reconstructed model performance in predicting [34] “raw” observations (Observed) and “refined” observations (Refined) of [34]. Performance of the model of [34] (Reference) in predicting “raw” observations is also shown. Rows: Correct and incorrect growth predictions (TP, FP), correct and incorrect no-growth predictions (TN, FN), total number of cases, sensitivity, specificity, precision and F1 score.