Gastrin binds to CCK-B receptor

Gastrin receptors (gastric cholecystokinin B receptor, CCK-BR) mediate acid secretion from parietal cells, release of histamine from enterochromaffin-like (ECL) cells and contraction of smooth muscle (Ito et al. 1993).The hormone gastrin is the central regulator of gastric acid secretion and in addition, plays a prominent role in regulation of growth and differentiation of gastric and colonic mucosa.

胃泌素受体（胃胆碱能B受体，CCK-BR）介导壁细胞分泌胃酸、肠嗜铬样细胞（ECL）释放组胺以及平滑肌（Ito et al. 1993）的收缩。激素胃泌素是胃酸分泌的中心调节因子，此外，在调节胃和结肠黏膜的生长与分化中亦发挥着显著作用。