Crystal structure of MerTK kinase domain in complex with Merestinib
收藏Protein Data Bank Japan2024-01-31 更新2026-03-21 收录
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Crystal structure of MerTK kinase domain in complex with Merestinib Descriptor: CHLORIDE ION, N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide, Tyrosine-protein kinase Mer Authors: Schimpl, M, Pflug, A, McCoull, W, Nissink, J.W.M, Overman, R.C, Rawlins, P.B, Truman, C, Underwood, E, Warwicker, J, Winter-Holt, J. Deposit date: 2020-09-05 Release date: 2020-10-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.87 Å) Cite: A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477, 2020
创建时间：
2020-09-05
