This project constructs a NOD/scid mouse digestive tract degenerative disease model by natural aging. Feces were collected from mice in the Young group(12-week-old ), the middle-aged group(32-week-old ),the solvent middle-aged group(32-week-old), the. NOD/SCID mouse gut metagenome

This project constructs a NOD/scid mouse digestive tract degenerative disease model by natural aging. Feces were collected from mice in the Young group(12-week-old ), the middle-aged group(32-week-old ),the solvent middle-aged group(32-week-old), the middle-aged + rFib group(32-week-old), the elderly group(43-week-old), and the elderly + rFib group(43-week-old).Using high-throughput metagenomic sequencing rechearch the changes in gut microbiota of aging mice and the changes in gut microbiota abundance and diversity of degenerative disease elderly mice induced by rFib cells were studied.