Transcriptome analysis in the Treatment of Diabetic Foot Ulcer Healing by Tibial Cortex Transverse Distraction

To investigate mRNA Expression profile and associated signaling pathways in the treatment of diabetic foot ulcer healing by tibial cortex transverse distraction. Methods: Tissue samples were collected from the wound edge before and after the surgery. After reference genome transcriptome sequencing and subsequent bioinformatics analysis, the differentially expressed genes and related pathways were explored, and functional analysis of important genes and pathways was conducted. In this study, we collected marginal tissue samples from patients with diabetic foot ulcers. By comparing the gene expression in the marginal tissues before and after TCTD, the differentially expressed genes in the tissues after TCTD were detected, and the associated signaling pathways were analyzed through bioinformatics analysis. This study helps us to better understand the molecular regulatory mechanism of TCTD in the healing process of diabetic foot ulcer.