scRNA-seq, Myeloid-Lineage Meta-Atlas

Myeloid-Lineage Single-Cell Meta-Atlas

This dataset contains a CNS single-cell RNA-seq myeloid meta-atlas used in the Savage et al. Nature (2026) study. This release includes a sparse cell-by-gene count matrix in Matrix Market format (207,997 cells), barcode and feature tables, harmonized cell-level metadata, sample-level metadata. The atlas spans 11 CNS-related conditions and contexts: Alzheimer’s disease, brain metastasis, development, glioma, healthy/control, medulloblastoma, multiple sclerosis, primary CNS lymphoma, Parkinson’s disease, primary GBM, and recurrent GBM.

Cell metadata provide harmonized annotations including cell ID, sample ID, study/cohort, etiology/diagnosis, and inferred state/subtype where available, together with original per-cell metadata retained from source objects. Sample metadata summarize the number of cells contributed by each sample. This resource is intended to support reproducible analysis of CNS myeloid heterogeneity and cross-study comparison.

Savage N., Grewal S., Shaikh V., Zemp F., McKenna D., Mikolajewicz N., Najem H., Pyczek J., Wei J., Taleb M., Asselstine L., Anand A., Chafe S., Zhai K., Maich W., Chokshi C., Patel H., Korman T., Subapanditha M., Shapovalova Z., Tatari N., Miltec P., Chen D., Pacheco S., Han H., Chan J., Brown K., Venugopal C., Kislinger T., Heimberger A., Moffat J., Mahoney D., Singh S. (2026). Dual tumor-myeloid targeting of glioblastoma with GPNMB CAR-T cells. Nature.