The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates Descriptor: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... Authors: Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. Deposit date: 2013-11-12 Release date: 2014-11-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.46 Å) Cite: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published

本数据集聚焦赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶（Farnesyl Pyrophosphate Synthase, FPPS）的催化活性、晶体结构及含氮双膦酸盐抑制效应的相关研究。数据集包含的物质描述如下：1,2-乙二醇、1-羟基-2-(3-吡啶基)亚乙基双膦酸、3-甲基丁-3-烯基三氢二磷酸酯等。作者团队：Tsoumpra, M.K、Barnett, B.L、Muniz, J.R.C、Walter, R.L、Ebetino, F.H、von Delft, F、Russell, R.G.G、Oppermann, U、Dunford, J.E。提交日期：2013-11-12；发布日期：2014-11-19；最后修改日期：2023-09-20。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率为1.46埃。引用文献：《赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶（FPPS）的催化活性、晶体结构及含氮双膦酸盐抑制作用研究》，待发表。