Nano-prison treated S. aureus

The abuse of broad bacterial killing agents leads to drug resistance, resulting in the failure of conventional antibiotic therapy. Antibacterial modalities derived from special nanomaterials have led to converging interest in infection treatment, due to the absence of natural bacterial defensive arsenals for these nanomaterials, which allows for circumventing bacterial resistance. Here, we demonstrate that a robust nanocoating, referred to as 'bacterial nano-prison', is a physical strategy for bacterial inhibition without drug resistance. Nano-prison maintains high mechanical strength at the microscopic scale to firmly constrain bacteria. We hypothesize that the nano-prison could interfere with the bacterial division process and biosynthesis process to achieve the purpose of bacterial inhibition. To test this hypothesis, we performed high-throughput RNA sequence of the control and nano-prison treated S. aureus.