The top six upstream regulators predicted by IPA to be inhibited in atretic versus healthy follicles.

†The predicted activation state is inferred from the bias-corrected z-score. The bias-corrected z-score is computed based on the proportion of target genes present in the data set which are directionally regulated as expected according to known effects of the regulator on the target compiled from the literature.
*The P value of overlap measures the statistical significance of overlap using Fisher's exact t-test between genes from the data set and those known to be acted upon by an upstream regulator.