074e2df0-10fb-4488-997a-f1a4c6dbceb2 - samples
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下载链接：
https://www.omicsdi.org/dataset/ega/EGAD00001011173
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资源简介：
In colorectal cancers (CRC) the tumor microenvironment plays a key role for prognosis and therapy efficacy. Patient-derived tumor organoids (PDTOs) show enormous potential for preclinical testing, however, purely epithelial cultures features including the ‘consensus molecular subtypes’ (CMS) are largely eradicated. To better reflect the cell type heterogeneity, we established the CRC organoid-stroma biobank of matched PDTOs and cancer-associated fibroblasts (CAFs) from 30 patients. Whole exome sequencing and transcriptome analysis in various in vitro and in vivo contexts was performed to study the influence of the TME on the CRC phenotype.EGA dataset EGAD00001011173
创建时间：
2023-07-20
