Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one

Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one Descriptor: (8S)-5-benzyl-2-({[(5P)-2-chloro-5-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl}amino)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION Authors: Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. Deposit date: 2023-02-08 Release date: 2024-02-21 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (2.026 Å) Cite: Crystal Structure of a human cyclic GMP-AMP synthase complex To be published

人源环状GMP-AMP合酶（cyclic GMP-AMP synthase）与5-苄基-2-[[2-氯-5-(1-甲基吡唑-3-基)苯基]甲氨基]-4H-[1,2,4]三唑并[1,5-a]嘧啶-7-酮复合物的晶体结构
描述：(8S)-5-苄基-2-({[(5P)-2-氯-5-(1-甲基-1H-吡唑-3-基)苯基]甲基}氨基)[1,2,4]三唑并[1,5-a]嘧啶-7(4H)-酮、环状GMP-AMP合酶、锌离子（ZINC ION）
作者：Leibrock L、Benz J、Groebke-Zbinden K、Rudolph M.G.
存储日期：2023-02-08
发布日期：2024-02-21
最后修改日期：2026-02-18
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.026埃（Å）
引用文献：《人源环状GMP-AMP合酶复合物晶体结构》（待发表）