Serum vibriocidal antibody titers and proportion of ≥4 fold rise from baseline GMT to V. cholerae O1 Inaba in all ages (≥ 6 years).

aGeometric mean reciprocal titers.bGeometric mean-fold rise from baseline to 14 days post first vaccine dose or from baseline to 14 days post second vaccine dose.cPercent of subjects with ≥ 4 fold rise in titers from baseline to 14 days post first vaccine dose or from baseline to 14 days post second vaccine dose. 95% confidence intervals derived using Wilson Score method.dDifference seroconversion rates (95% CI) after single dose are calculated by subtracting those following primary series from those following booster dose. In the aged ≥ 6 years old group, seroconversion rates following single booster dose (71%) is noninferior than those following one dose of a primary series (78%) as the lower limit of the proportion difference is greater than clinical margin (-20%)eDifference seroconversion rates (95% CI) after two doses are calculated by subtracting those following primary series from those following booster doses. In the aged ≥ 6 years old group, seroconversion rates following two booster doses (66%) is noninferior than those following two doses primary series (69%) as the lower limit of the proportion difference is greater than clinical margin (-20%)Serum vibriocidal antibody titers and proportion of ≥4 fold rise from baseline GMT to V. cholerae O1 Inaba in all ages (≥ 6 years).