CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00420737-09 AT 2.00 A RESOLUTION
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00420737-09 AT 2.00 A RESOLUTION Descriptor: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-{3-[(5-methylthiophen-2-yl)ethynyl]phenyl}-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ... Authors: Davies, D.R, Dranow, D.M. Deposit date: 2019-08-02 Release date: 2020-09-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
分辨率为2.00埃的乳酸脱氢酶A（LDHA）与化合物NCGC00420737-09复合物的晶体结构
描述符：1,2-乙二醇、1,4-二氢烟酰胺腺嘌呤二核苷酸、2-[5-(环丙基甲基)-4-[(3-氟-4-氨磺酰基苯基)甲基]-3-{3-[(5-甲基噻吩-2-基)乙炔基]苯基}-1H-吡唑-1-基]-1,3-噻唑-4-羧酸……
作者：Davies, D.R.、Dranow, D.M.
入库日期：2019-08-02
发布日期：2020-09-23
最后修改日期：2023-10-11
实验方法：X射线衍射（2埃）
引用文献：《具有优化细胞活性与药代动力学特性的吡唑类乳酸脱氢酶抑制剂》，J.Med.Chem., 63, 2020
创建时间：
2019-08-02
