Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027

Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027 Descriptor: 1,2-ETHANEDIOL, 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF Authors: Chan, A, Schonbrunn, E. Deposit date: 2020-09-21 Release date: 2020-12-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020

人类含溴结构域与PHD锌指的转录因子（Bromodomain and PHD finger-containing Transcription Factor，缩写BPTF）的溴结构域（bromodomain, BD）与GSK4027结合的晶体结构。配体描述：1,2-乙二醇（1,2-ETHANEDIOL）、4-溴-2-甲基-5-[[(3R,5R)-1-甲基-5-苯基哌啶-3-基]氨基]哒嗪-3-酮。BPTF为核小体重塑因子亚基。作者：Chan, A、Schonbrunn, E。提交日期：2020-09-21，发布日期：2020-12-09，最后修改日期：2023-10-18。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.6 Å）。引用文献：《基于结构生物学与生物物理测定开发的BPTF溴结构域新型抑制剂》，《有机与生物分子化学》（Org.Biomol.Chem.），18卷，2020年。