Adolescent Master Protocol for Participants 18 Years of Age and Older - Lite, PH400

This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term mental and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, specimen collection, and medical chart abstraction, designed to achieve the primary objectives, as well as the domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.