DNA methylation atlas of rat kidney under tubulointerstitial fibrosis

In renal tubulointerstitial fibrosis (TIF), aberrant changes in renal drug transporters severely disrupt systemic drug disposition, leading to reduced therapeutic efficacy or increased toxicity. Although we have previously documented transporter alterations in TIF, the underlying epigenetic mechanisms remain unknown. This study aims to map the DNA methylation landscape of TIF, elucidate the epigenetic network governing transporter dysregulation, and provide mechanistic insights to support safer drug use in CKD.