RNAseq of wild type and GDF11-/- Neuro-2a cells

Growth differentiation factor 11 (GDF11), is one of the members of transforming growth factor ß (TGFß) superfamily. We set out to unequivocally reveal the effect of endogenous GDF11 on biological process by adopting CRISPR/Cas9 gene knockout strategy to specifically delete GDF11 gene in Neuro-2a cells. We analyze mRNA profiles of differentially genes in wild type (WT) and GDF11 knockout (GDF11-/-) Neuro-2a cells by using RNA-seq technology. The RNA-seq data reported here provide a fundamental materials and evidence for investigations of biological function of GDF11. Overall design: Examination of mRNA profiles in wild type (WT) and GDF11-/- Neuro-2a cells.