The effect of early life social stress on mouse Ventral Tegmental Area transcriptomic profile

This study investigated the impact of psychosocial stress experienced during adolescence on the development of the brain dopaminergic system. The experiment was designed to evaluate the transcriptomic changes in the ventral tegmental area of mouse brain after one week of repeated exposure to a threatening mouse during preadolescence (P14-P21). We performed comparison between the ventral tegmental area mRNA profiles of P21 Social Stressed (SS) mice (n=5) and P21 unhandled control (CTR) (n=5) mice - two experimental groups.