Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4c
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Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4c Descriptor: (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-(2-phenylethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. Deposit date: 2024-09-16 Release date: 2025-09-24 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
人溶酶体酸性α-葡糖苷酶（GAA）与亚氨基糖化合物4c结合的晶体结构
组分：(2R,3R,4R,5S)-2-(羟甲基)-2-(2-苯乙基)哌啶-3,4,5-三醇、1,2-乙二醇、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，……
作者：Sulzenbacher G、Roig-Zamboni V、Moracci M、Parenti G、Py S
存储日期：2024-09-16
发布日期：2025-09-24
最后修改日期：2025-10-08
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.8 Å
引用：《C-支链亚氨基糖作为溶酶体α-葡糖苷酶的选择性药理分子伴侣用于庞贝病治疗》，《药物化学杂志（J.Med.Chem.）》，2025年，第68卷
创建时间：
2024-09-16
