Supplementary datasets accompanying "The Genetic Architecture of Cutaneous Melanoma Across the Variant Spectrum"

This repository contains key datasets generated in the study “The Genetic Architecture of Cutaneous Melanoma Across the Variant Spectrum.” It includes: (1) genome-wide association meta-analysis summary statistics for cutaneous melanoma, comprising 1,398,034 individuals (55,006 cases and 1,343,028 controls); (2) functional annotations derived from Variant Effect Predictor (VEP) for 1,198 fine-mapped candidate causal variants across 143 credible sets (posterior inclusion probability ≥ 0.99); and (3) PRS-CS weight files for 22 autosomes used to compute common-variant polygenic risk scores (cvPRS). Code used in the analyses is available at:https://github.com/shiyuzhang0522/Genetic_Architecture_of_Cutaneous_Melanoma