C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

C2CD3 and the centrosome component OFD1 are required for the recruitment of distal appendage proteins CEP164, CEP83/CCDC41, CEP89, FBF1 and SCLT1 to the mother centriole (Ye et al, 2014; Tang et al, 2013; Singla et al, 2010). Distal appendage proteins are believed to form part of the transition fibres that anchor the basal bodies to the actin rich cortex at the base of the emerging cilium, and are also required for the recruitment and binding of ciliary vesicles and intraflagellar transport (IFT) complexes (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2010; Schmidt et al, 2012; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014).

C2CD3及其中心体成分OFD1对于将远端附件蛋白CEP164、CEP83/CCDC41、CEP89、FBF1和SCLT1招募至母中心粒至关重要（Ye et al，2014；Tang et al，2013；Singla et al，2010）。据信，远端附件蛋白构成了过渡纤维的一部分，这些纤维将基体锚定于新形成纤毛底部的富含肌动蛋白的皮质，并对于纤毛泡和内节转运（IFT）复合物的招募与结合亦属必需（Tanos et al，2013；Wei et al，2013；Joo et al，2010；Schmidt et al，2012；Sillibourne et al，2013；Ye et al，2014；详见Winey和O'Toole，2014年综述）。