Asymmetric Conjugate Addition of Silyl Enol Ethers Catalyzed by Tethered Bis(8-quinolinolato) Aluminum Complexes

New chiral tethered bis(8-quinolinolato) (TBOx) aluminum(III) complexes effectively catalyze the highly enantioselective Mukaiyama−Michael reaction of silyl enol ethers, including tetrasubstituted enolates that give rise to enantioenriched α-carbonyl all-carbon-substituted quaternary stereocenters. The present catalyst also promotes the conjugate addition of N-benzylindole to α,β-unsaturated acylphosphonates with high enantioselectivity (indole Friedel−Crafts alkylation reaction).