Cyclin D1, Id2 and Sox9 are upregulated in a lobular competent COMMA Db clonal derivative’ cells compared to a lobular incompetent clone both in vitro, and in vivo

Understanding underlying mechanisms responsible for the differentiation and stemness of mouse mammary progenitor cells are paramount to understanding the heterogeneity of mammary development and tumorigenesis. Consequently, studies have isolated and characterized mouse mammary progenitor cell lines such as: COMMA-1D, NSP2 and SP3, but have not parsed the various transcriptomes that play a role in progenitor differentiation and mammary gland development. Using microarray technologies, we analyzed transcriptomes, from Comma Db clonal derivatives, SP3 and NSP2, during different mouse mammary growth phases: In-vitro, In-vivo 5 weeks, and In-vivo 12 weeks.