Bacteriophage sp. strain:Klebsiella pneumoniae Genome sequencing. Bacteriophage sp. strain:Klebsiella pneumoniae

Phage specificity, known as targeting bacterial strain precisely, is regarded as a significant obstacle to the development of phage therapy. This specificity is directly linked to the key step recognition between phage receptor-binding protein and phage receptors on the susceptible host cells. Mutating phage receptors to block the interaction between phage receptor and phage receptor-binding protein to prevent phage adsorption can be the first step that bacterial cells exhibit in developing resistance to avoiding infection. In order to establish efficient phage therapy in clinical practice, a detailed understanding of phage-host interactions is needed before solid, reproducible treatments of various diseases is available.