Gene expression profiling of human MSC-educated macrophages vs. classical macrophages from bone marrow and blood
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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In comparison to MÃs, MEMs have increased expression of the inhibitory molecules PD-L1, PD-L2, in addition to markers of alternatively activated macrophages: CD206 and CD163. RNA-Seq analysis of MEMs, as compared to MÃs, show a distinct gene expression profile that positively correlates with multiple pathways important in tissue repair. MEMs also show increased expression of IL-6, TGF-β, Arginase-1, CD73, and decreased expression of IL-12 and TNF-α. We show that IL-6 secretion is controlled in part by the COX-2, arginase and JAK1/STAT1 pathway. When tested in vivo, we show that human MEMs significantly enhance survival from lethal GVHD, and improve survival of mice from radiation injury.
提供机构：
University of Wisconsin
创建时间：
2022-02-20
