Gut microbiota in an infant with propionic acidemia before and after probiotic supplementation

In the present project we described the results of the investigation on gut microbiota composition of an infant diagnosed with propionic acidemia (a rare metabolic disease) following standard therapy (antibiotic treatment and diet monitoring)Microbiota composition was assessed during the first month of life and at the age of 4 months when the infant received supplementation of well-characterized probiotic bifidobacteria (low dosage mixture of 3 three strains).Molecular analyses were performed with both metabarcoding and low coverage whole metagenome sequencing.