Ribo-depleted RNA-seq data of Drosophila dcr-1 KD. Drosophila melanogaster

Recent studies have increasingly pointed to microRNAs (miRNAs) as the agent of GRN (gene regulatory network) stabilization as well as developmental canalization against constant but small environmental perturbations. Since the complete removal of miRNAs is lethal, we construct a Dicer-1 knockdown line (dcr-1 KD) in Drosophila that modestly reduces all miRNAs. To study the impact of dcr-1 KD on transcriptional regulation, we collected the late third instar larvae from dcr-1 KD and wildtype flies and performed ribo-depleted RNA-seq analysis.