CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF.

CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF. Descriptor: 2-[4-((2-AMINO-4-OXO-3,4-DIHYDRO-PYRIDO[3,2-D]PYRIMIDIN-6-YLMETHYL)-{3-[5-CARBAMOYL-3-(3,4- DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-3H-IMIDAZOL-4-YL]-ACRYLOYL}-AMINO)-BENZOYLAMINO]- PENTANEDIOIC ACID, Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, ... Authors: Wolan, D.W, Greasley, S.E, Wall, M.J, Benkovic, S.J, Wilson, I.A. Deposit date: 2003-04-07 Release date: 2003-09-30 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor beta-DADF Identifies the Folate Binding Site. Biochemistry, 42, 2003

禽源ATIC（Avian ATIC）同源二聚体双功能甲酰转移酶/环水解酶结合多底物加合物抑制剂β-DADF的晶体结构。描述物：2-[4-((2-氨基-4-氧代-3,4-二氢吡啶并[3,2-d]嘧啶-6-基甲基)-{3-[5-氨基甲酰基-3-(3,4-二羟基-5-膦酰氧基甲基-四氢呋喃-2-基)-3H-咪唑-4-基]-丙烯酰基}-氨基)-苯甲酰基氨基]-戊二酸；双功能嘌呤生物合成蛋白PURH；磷酸根离子等。作者：Wolan D.W.、Greasley S.E.、Wall M.J.、Benkovic S.J.、Wilson I.A.。提交日期：2003年4月7日；发布日期：2003年9月30日；最后修改日期：2023年8月16日。实验方法：X射线衍射（分辨率2.5埃）。引用文献：《结合多底物加合物抑制剂β-DADF的禽源AICAR甲酰转移酶结构鉴定叶酸结合位点》，《生物化学》，第42卷，2003年。