Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(3- fluorophenyl)propan-1-amine

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(3- fluorophenyl)propan-1-amine Descriptor: 3-(3-fluorophenyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}propan-1-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2014-10-20 Release date: 2014-12-24 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015

牛内皮型一氧化氮合酶（bovine endothelial nitric oxide synthase）血红素结构域与N-2-(2-(1H-咪唑-1-基)嘧啶-4-基)乙基-3-(3-氟苯基)丙-1-胺的复合物结构。配体描述符：3-(3-氟苯基)-N-{2-[2-(1H-咪唑-1-基)嘧啶-4-基]乙基}丙-1-胺、5,6,7,8-四氢生物蝶呤、乙酸根离子……作者：Li, H、Poulos, T.L. 提交日期：2014-10-20，发布日期：2014-12-24，最后修改日期：2024-11-13。实验方法：X射线衍射（2.18 Å）。引用文献：《新型2,4-二取代嘧啶类强效、选择性且细胞可透过性神经元型一氧化氮合酶抑制剂》，《药物化学杂志（J.Med.Chem.）》，第58卷，2015年。