Rhodium-Catalyzed [(3+2)+1] Carbocyclization Reactions of Alky­nylidene­cyclo­propanes with Carbon Monoxide: Regiospecific Construction of Polysubstituted Phenols

The development of the rhodium-catalyzed [(3+2)+1] carbocyclization reaction of alky­nylidene­cyclo­propanes with carbon monoxide to construct polysubstituted phenols is described. This work offers a convenient method for the selective formation of tetra- and pentasubstituted phenols, which provide important intermediates for target directed synthesis. Finally, the ability to regiospecifically functionalize the phenols using conventional methods further illustrates the utility of this process.