Definition of the reactions in the spatial-temporal simulations.

Initial concentrations (nM) are Ru (varied), EGF = 20.42VolExtracellular (VolExtracellular is the volume of the cell (diameter of 20 µm) multiplied by the ratio of the volume of incubation medium per cell over the cytoplasmic water volume ∼33.3), PLCγ = 105, Grb2 = 85, and Sos = 34. First and second-order rate constants are in units of s−1 and nM−1 s−1 and the Michaelis-Menten constants Km and Vmax are in units of nM and nM s−1, respectively. Reactions are categorized as membrane reactions (handled by the SKMC), interfacial reactions (cytosolic species associating or dissociating with receptor) handled by the SKMC, and cytosolic reactions (handled by the SSA).