Design of fast redox-controlled self-immolative selenium-based cysteine surrogates

The self-immolation of N-selenoethyl cysteine derivatives into cysteine exhibits a strong Thorpe-Ingold effect. Notably, the gem-dimethyl substitution alpha to the selenium atom achieved rate accelerations up to 252-fold, enabling Cys unmasking through C-N bond cleavage within minutes. These investigations offer valuable insights into the mechanism of selenoethyl arm breakdown and new redox-sensitive Cys surrogates., , # Design of fast redox-controlled self-immolative selenium-based cysteine surrogates

[https://doi.org/10.5061/dryad.2bvq83c2q](https://doi.org/10.5061/dryad.2bvq83c2q)

## Description of the data and file structure

We have submitted our nuclear magnetic resonance (NMR) data for structure elucidation of all the chemical intermediates involved in the synthesis of Fmoc-MeSetCys-OH and Fmoc-Me2SetCys-OH (FID NMR.7z).

This dataset includes raw NMR data files for all NMR spectra presented in this manuscript. Raw data files are stored in subfolders corresponding to compound name. Each numerically named subfolder represents the data for a single spectrum and can be directly opened with the Bruker’s TopSpin software mentioned in the following “Usage Notes.”

All these folders should contain all the required information to access the data and interactively view the NMR spectra. A more detailed list of the files is provided at the end of this README file.

## Usage notes

For viewing NMR raw da...,