Chronic Hand Eczema, learning from clinical characterization, aetiology, concomitant foot eczema and polysensitization

Supplementary data for the publication: Chronic Hand Eczema, learning from clinical characterization, aetiology, concomitant foot eczema and polysensitization.
Summary: Background. Chronic hand eczema (CHE) is a disabling dermatosis that shows concomitant conditions, such as foot eczema and contact sensitization. Objectives. To identify the characteristics of CHE population in Spain: with special emphasis on occupational dermatitis, evaluation of concomitant foot eczema and of polysensitization phenomenon.Methods. 2,926 patch-tested patients presenting CHE from different specialized Dermatological Units were evaluated. A global descriptive characterization was performed for different subgroups, as well as an evaluation of polysensitization. Results. The first diagnostic for CHE was irritant contact dermatitis (42%) and for patients with foot-and-chronic hand eczema (FCHE) it was allergic contact dermatitis (28%). A 39% of CHE showed occupational relevance. Positivity for at least one allergen was found in 55% of patients, with nickel sulphate and methylisothiazolinone (MI) as the most prevalent. Methylchloroisothiazolinone (MCI)/MI, nickel sulphate and potassium dichromate showed the highest occupational relevance. 236 cases presented concomitant FCHE (8%, 46% men) with higher percentages of positivity for potassium dichromate and cobalt chloride. Twelve percent of patients with CHE were polysensitized, with MI as the most frequent allergen. Conclusions. Patch test for FCHE and CHE shows a specific contact allergen and occupational profile. Methylisothiazolinone appeared as the most related allergen to polysensitization in CHE.

补充数据集描述：慢性手部皮炎，基于临床特征、病因、并发足部皮炎和多过敏原性研究。摘要：背景。慢性手部皮炎（CHE）是一种致残性皮肤病，常伴随足部皮炎和接触性敏感化等并发症状。研究目的。旨在识别西班牙CHE人群的特征：特别强调职业性皮炎，评估并发足部皮炎和多过敏原现象。研究方法。对来自不同专业皮肤科单位的2,926名进行斑贴试验的CHE患者进行了评估。对不同的亚组进行了全面的描述性分析，并对多过敏原性进行了评估。研究结果。CHE的首诊为刺激接触性皮炎（42%），而对于足部及慢性手部皮炎（FCHE）患者则为过敏性接触性皮炎（28%）。39%的CHE患者与职业相关。55%的患者至少对一种过敏原呈阳性，其中硫酸镍和甲基异噻唑啉酮（MI）最为常见。甲基氯异噻唑啉酮（MCI）/MI、硫酸镍和重铬酸钾显示出最高的职业相关性。236例（8%，其中46%为男性）患者呈现并发FCHE，对重铬酸钾和钴氯化物的阳性率较高。12%的CHE患者为多过敏原性，其中MI为最常见的过敏原。结论。FCHE和CHE的斑贴试验显示出特定的接触性过敏原和职业特征。甲基异噻唑啉酮在CHE的多过敏原性中显示出与多过敏原性最相关的过敏原。