Serratia marcescens Chitinase B complexed with macrolide inhibitor 29

Serratia marcescens Chitinase B complexed with macrolide inhibitor 29 Descriptor: (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ethyl-2,10-dihydroxy-2,6,8,10,12,15,15,17-octamethyl-5-oxo-9-(prop-2-yn-1-yloxy)-4,14,16-trioxabicyclo[11.3.1]heptadec-7-yl {2-[N'-(methylcarbamoyl)carbamimidamido]ethyl}carbamate, CHLORIDE ION, Chitinase B, ... Authors: Maita, N, Sugawara, A, Sunazuka, T. Deposit date: 2015-03-30 Release date: 2015-07-01 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase J.Med.Chem., 58, 2015

粘质沙雷氏菌（Serratia marcescens）几丁质酶B（Chitinase B）与大环内酯类抑制剂（macrolide inhibitor）29形成的复合物。描述符：(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-乙基-2,10-二羟基-2,6,8,10,12,15,15,17-八甲基-5-氧代-9-(丙-2-炔-1-基氧基)-4,14,16-三氧杂双环[11.3.1]十七烷-7-基 {2-[N'-(甲基氨基甲酰基)胍基]乙基}氨基甲酸酯、氯离子（CHLORIDE ION）、几丁质酶B…… 作者：Maita N、Sugawara A、Sunazuka T。保藏日期：2015-03-30；发布日期：2015-07-01；最后修改日期：2024-10-16。结构解析方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.35埃）。引用文献：《14元大环内酯骨架的定制生物活性构建：基于18家族几丁质酶的设计、合成与生物活性评价》，发表于《Journal of Medicinal Chemistry》（J.Med.Chem.），58卷，2015年。