Polycomb repressive complex 1 (PRC1) role in skin epithelium development [Epidermis I53A]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Polycomb repressive complexes (PRC) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiquitination (H2AK119ub) and catalytic-independent activities. Here, we show that despite its well-established repressor functions, PRC1 binds to both silent and active genes. Through in vivo loss-of-function studies, we show that global PRC1 function is essential for skin development and stem cell (SC) specification.
提供机构：
Yale School of Medicine
创建时间：
2022-02-20
