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Transcriptomic analysis of MSTO-211H cell variant resistant to CAR T cell therapy

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156621
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We developed MPM cells from pleural tumors that had relapsed after treatment with M28z CAR T cells We implanted MSTO-211H in the pleura of NSG mice and after 2 weeks we treated mice with CAR T cells. Tumor from mice that relapsed ( 3 mice) were isolated and cells culture in vitro. We generated 3 cell variants from relapsed tumors
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2021-09-30
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