Pneumococcus rolls epigenetic dice with a six phase random switch that controls virulence. Streptococcus pneumoniae

We sequenced mRNA form 4 Streptococcus pneumoniae which expressed only a single HsdS variant of the phase variable type I restriction modification system. Samples were from mid log exponential growth phase in standard glucose containing growth medium. Overall design: Examination of the mRNA profiles for evaluation of epigenetic regulation by a phase variable restriction modification system