Kmt2a and Kmt2b Control Memory Function via Different Transcriptional Programs. Mus musculus

We have analyzed changes in histone 3 lysine 4 methylation (H3K4me) and gene expression resulting either from Kmt2a or Kmt2b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown either of these histone methyltransferases in excitatory forebrain neurons in adult mice. Overall design: Examination of H3K4me3 and H3K4me1 levels, and gene expression in hippocampal CA neurons of of adult Kmt2a cKO and Kmt2b cKO mice.