Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-02-23 Release date: 2022-08-31 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022

结合ATP与格列本脲（glibenclamide）且Kir6.2-CTD处于向上构象的胰腺ATP敏感性钾通道的冷冻电镜（Cryo-EM）结构 描述符：(2S)-3-(十六烷酰氧基)-2-[(9Z)-十八碳-9-烯酰氧基]丙基 2-(三甲基铵基)乙基磷酸酯、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、5-氯-N-(2-{4-[(环己基氨基甲酰)磺酰基]苯基}乙基)-2-甲氧基苯甲酰胺…… 作者：Shyng, S.L.、Sung, M.W.、Driggers, C.M. 存档日期：2022-02-23 发布日期：2022-08-31 最后修改日期：2024-11-13 实验方法：冷冻电镜法（分辨率3.58埃） 引用：《哺乳动物胰腺ATP敏感性钾通道的配体介导结构动力学》，《分子生物学杂志》（J.Mol.Biol.），434卷，2022年