Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK2032710A at 2.28A resolution Descriptor: 1,2-ETHANEDIOL, HTH-type transcriptional regulator EthR, [4-(phenylmethyl)piperidin-1-yl]-[1-(5-pyrrol-1-yl-1,3,4-thiadiazol-2-yl)piperidin-4-yl]methanone Authors: Mendes, V, Blaszczyk, M, Mugumbate, G, Blundell, T.L. Deposit date: 2017-01-27 Release date: 2017-10-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Front Pharmacol, 8, 2017

结核分枝杆菌（Mycobacterium Tuberculosis）转录调控阻遏蛋白EthR与化合物GSK2032710A复合物的晶体结构，分辨率为2.28埃
描述项：1,2-乙二醇、螺旋-转角-螺旋（HTH）型转录调节因子EthR、[4-(苯甲基)哌啶-1-基]-[1-(5-吡咯-1-基-1,3,4-噻二唑-2-基)哌啶-4-基]甲酮
作者：Mendes V、Blaszczyk M、Mugumbate G、Blundell T.L.
提交日期：2017-01-27
发布日期：2017-10-25
最后修改日期：2024-01-17
实验方法：X射线衍射（2.28埃）
引用文献：《采用协同化学基因组学、生物物理与结构生物学方法鉴定结核分枝杆菌表型活性化合物靶点》，《前沿药理学》（Front Pharmacol），第8卷，2017年