Distinct DNA methylation landscape between pediatric brain and adult brain

Epigenetics tightly regulates gene expression during brain development, which ensemble distinct cell types and form complicated functional brain organ. DNA methylation is an important mark which undergo dramatically changes during brain development. The disturb of this process will lead to various brain tumors. To study the concordant DNA methylation changes during normal brain development, we sequenced DNA methylome of pediatric brain tissues from autopsy with various ages. We systematically compared the DNA methylome of pediatric brain and adult brain and identified candidate DMRs that contribute to normal brain development. This comprehensive analysis will provide important epigenetic reference for human brain development which will be a valuable data to study the epigenetic mechanism of pediatric brain tumor. We sequenced DNA methylomes of pediatric brain tissues from autopsy; We systematically compared DNA methylome between pediatric and adult brain.