Rhodium(I)-Catalyzed Highly Enantioselective Insertion of Carbenoid into Si–H: Efficient Access to Functional Chiral Silanes
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https://figshare.com/articles/dataset/Rhodium_I_Catalyzed_Highly_Enantioselective_Insertion_of_Carbenoid_into_Si_H_Efficient_Access_to_Functional_Chiral_Silanes/2072710
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资源简介：
The first rhodium(I)-catalyzed
enantioselective Si–H insertion
reaction of α-diazoesters and α-diazophosphonates has
been developed. The use of a C1-symmetric
chiral diene ligand enabled the asymmetric reaction to proceed under
exceptionally mild conditions and give versatile chiral α-silyl
esters and phosphonates with excellent enantioselectivities (up to
99% ee). The mechanism and stereochemical pathway of this novel Rh(I)-carbene-directed
Si–H insertion was investigated by deuterium kinetic isotope
effect experiments and DFT calculations.
创建时间：
2017-12-26
