Enriched KEGG pathways among genes in the top 100 interactions.

The top row gives the number of unique genes present in the top 100 miR-mRNA interactions according to each model; the remaining rows give, per column, the number of these genes annotated by KEGG pathway terms with significant enrichment (FDR corrected ) for for at least one of the models proposed. A blank entry indicates that the particular pathway was not significantly enriched in the model. The column G–O refers to the grouped-ordered model version, I–O is the individual-ordered model version, and I-R is the individual-reference model version, while Neg.Cor is the ranking by most negative Pearson correlation (between miR and mRNA expression profiles) among the predicted target pairs. The horizontal lines separate general categories of KEGG pathways, namely cancer-related pathways, other disease-related pathways, and then remaining pathways found to be enriched by at least one of the models.