Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C

A short,
enantioselective synthesis of (−)-nodulisporic
acid C is described. The route features two highly diastereoselective
polycyclizations en route to the terpenoid core and the indenopyran
fragment and a highly convergent assembly of a challenging indole
moiety. Application of this chemistry allows for a 12-step synthesis
of the target indoloterpenoid from commercially available material.