White body nanoLC ESI-MS/MS analysis in the cephalopod Sepia officinalis

Cephalopods, like other Protostomes, lack an adaptive immune system and only rely on an innate immune system. The main immune cells are haemocytes, able to respond to pathogens and external attacks. First reports based on morphological observations suggested that the white body located in the optic sinuses of cuttlefish was at the origin of haemocytes. We performed a shotgun analysis of the proteome of the white body in cutllefish in order to confirm haematopoietic function and explore additional function.