Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach

Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Dual specificity protein kinase TTK Authors: Innocenti, P, Woodward, H.L, Solanki, S, Naud, N, Westwood, I.M, Cronin, N, Hayes, A, Roberts, J, Henley, A.T, Baker, R, Faisal, A, Mak, G, Box, G, Valenti, M, De Haven Brandon, A, O'Fee, L, Saville, J, Schmitt, J, Burke, R, van Montfort, R.L.M, Raymaud, F.I, Eccles, S.A, Linardopoulos, S, Blagg, J, Hoelder, S. Deposit date: 2015-10-28 Release date: 2016-11-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach To Be Published

基于结构杂合化策略快速发现单极纺锤体激酶1（Monopolar Spindle kinase 1, MPS1）的吡啶并[3,4-d]嘧啶（Pyrido[3,4-d]pyrimidine）类抑制剂
描述符：1-[3-叔丁基-1-(4-甲基苯基)-1H-吡唑-5-基]脲，双特异性蛋白激酶TTK（Dual specificity protein kinase TTK）
作者：Innocenti P、Woodward H.L.、Solanki S、Naud N、Westwood I.M.、Cronin N、Hayes A、Roberts J、Henley A.T.、Baker R、Faisal A、Mak G、Box G、Valenti M、De Haven Brandon A、O'Fee L、Saville J、Schmitt J、Burke R、van Montfort R.L.M.、Raymaud F.I.、Eccles S.A.、Linardopoulos S、Blagg J、Hoelder S
入库日期：2015-10-28
发布日期：2016-11-09
末次修改日期：2024-05-08
实验方法：X射线衍射（分辨率2.66埃）
引用文献：基于结构杂合化策略快速发现单极纺锤体激酶1（MPS1）的吡啶并[3,4-d]嘧啶类抑制剂（待发表）